The yin and yang of kidney development and Wilms' tumors.

The Yin and Yang of kidney development and Wilms’ tumours

A 15-year Clinicopathologic Evaluation Of Wilms’ Tumor In Referrals Of Children Hospital

Background and Objective: Wilms’ tumor has been recognized as the most common primary malignancy of kidney at childhood, comprises 5-6% of tumors in this period, and manifests itself with various clinical symptoms. Since there have been no sufficient studies in this field in Iran, therefore, this study w...

LINking microRNAs, kidney development, and Wilms tumors.

In this issue of Genes & Development, Urbach and colleagues (pp. 971-982) provide compelling data suggesting a role for LIN28 in the pathogenesis of a significant percentage of Wilms tumors. These data extend our insights in the genetics underlying Wilms tumor development and emphasize the importance of stemness and microRNA-mediated processes in the origins of these tumors.

MiR-21 Expression in Wilms’ Tumor

Background and Objective: Wilms’ tumor (WT) is the most common genitourinary tract tumor in children. MicroRNAs (miRNAs) are small non-coding RNAs; their role in the pathogenesis of many types of human cancers has been identified. We aimed to evaluate the expression of miR-21, a well-known oncomir, in WT tissue samples which is a very common urinary tract malignancy in children...

Kidney : Nephroblastoma ( Wilms tumor )

Other names: Nephroblastoma Note: Wilms' tumor, although generally rare, is the most common abdominal malignancy in children. Wilms' tumor cells are believed to derive from pluripotent embyronic renal precursor cells. Thus, Wilms' tumors are linked to the early development of the kidney. While most are isolated sporadic tumors, approximately 10% of cases are associated with genetic syndromes an...